Merriam-Webster Collegiate Dictionary - estral cycle

 noun  Date: 1941 estrous cycle ESTRANGE  transitive verb  (~d; estranging)  Etymology: Middle English, from Anglo-French estrangir, ~r, from Medieval Latin extraneare, from Latin extraneus strange — more at strange  Date: 15th century  1. to remove from customary environment or associations  2. to arouse especially mutual enmity or indifference in where there had formerly been love, affection, or friendliness ; alienate  • ~ment noun  • ~r noun Synonyms:  ~, alienate, disaffect mean to cause one to break a bond of affection or loyalty. ~ implies the development of indifference or hostility with consequent separation or divorcement his ~d wife. alienate may or may not suggest separation but always implies loss of affection or interest managed to alienate all his coworkers. disaffect refers especially to those from whom loyalty is expected and stresses the effects (as rebellion or discontent) of alienation without actual separation troops disaffected by hunger.